Professor Roger Seheult, MD gives practical strategies if you test positive for COVID-19 (or are in contact with someone who tests positive) including:
COVID-19 is a novel respiratory disease that can damage the lining of the air sacs in the lungs. In severe cases, COVID-19 affects breathing, and patients may even need ventilator support. And those with lung disease are more vulnerable. “If you’re a smoker and need a reason to quit, let this pandemic be your reason” . With lung cancer the leading cause of cancer death in men and women in the U.S., avoiding cigarettes and vaping is always a good rule to follow. “If quitting smoking doesn’t save you from coronavirus, it could save your life down the road. So, stop smoking. That’s the number-one thing you can do to improve your immune system as a modifiable risk.”
Cortisol, the stress hormone, reduces the activity of the immune system. Stress can also impact our sleep. “When you’re anxious and you’re turning things over in your mind and can’t stop thinking about them, your sleep will be negatively affected by that”
He same goes for eating habits. When we’re stressed, we’re more likely to make bad decisions, like eating unhealthy foods, which can have a domino effect on our overall health. Look for ways to help manage anxiety during the outbreak.
“Now is a great time to work on self-betterment,” . “At a time like this, when so much of what’s happening is outside of our control, it’s deeply empowering to focus on the aspects of our immunity and resilience that we can control, giving us a sense of well-being that we’re doing everything in our power to stay healthy.”
“Eating a well-rounded, balanced diet, like the Mediterranean diet, that’s packed with vegetables, lean meats, and healthy fats is another way people can improve their immune system” . A plant-based diet has similar data behind it in terms of infection prevention.
“The majority of the immune system is found in the lining of your intestine, so it’s a good idea to support your gut and microbiome with lots of good bacteria,” he says. Many people look to probiotics to supplement their gut with good bacteria. The importance of a whole-foods diet rather than taking a probiotic supplement — unless you’re taking probiotics for a specific purpose, such as irritable bowel syndrome. Consider adding foods that are rich in probiotics to your diet, such as yogurt or fermented foods like kimchi, miso, and sauerkraut.
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How can nutrition support immune health?
The immune system needs energy and a variety of nutrients to produce a functional immune response. Specific nutrients impact the physiological mechanisms involved in the inflammatory response, such as the recruitment of immune cells and chemical mediators that communicate between cells in the immune system.
What are antioxidants?
Some nutrients can act as antioxidants, which counteract free radical production that occurs as a natural part of the inflammatory response. Balancing levels of reactive oxygen species during the inflammatory response is an important step to make sure unwarranted damage is not done to the body while the immune system fights an infection.
Micronutrients and phytonutrients that serve as antioxidants include:
Other dietary components involved in immunity:
Medicinal mushrooms (Maitake; Turkey Tail)
Whole food fermentate
Omega-3 fatty acids
Nutritional Antioxidants Prevent Collateral Damage
Antioxidants are needed to protect tissue from damage due to the production of free radicals during the inflammatory process. The need for antioxidants is essential for either acute or chronic inflammation.4-5 A balance between reactive oxygen species formation, free radical production, and endogenous antioxidant defense mechanisms is needed to avoid tissue damage to DNA, proteins, and membrane lipids.
In addition to the traditional antioxidants found in the diet such as vitamin E and vitamin C, carotenoids (lycopene and beta-carotene), plant polyphenols, and resveratrol, there are less well known antioxidants.6-7 Gallic acid (3,4,5-trihydroxybenzoic acid) is a powerful phenolic antioxidant naturally found in foods and herbs. Gallic acid inhibits mast cell-derived inflammatory allergic reactions by blocking histamine release and pro-inflammatory cytokine expression.8 Gallic acid is present in most plants and exhibits bioactivity as an antioxidant, antimicrobial, anti-inflammatory, neuroprotective, and anti-cancer agent.9-10
|Superoxide anion||Generated in mitochondria, cardiovascular system, and other cell types|
|Hydrogen peroxide||Formed in the human body by a large number of reactions and yields potent reactive species|
|Hydroxyl radical||Highly reactive; generated during iron overload and such conditions in the human body|
|Peroxyl radical||Reactive; forms lipids, proteins, DNA, and sugar molecules during oxidative damage|
|Nitric oxide||Neurotransmitter associated with blood pressure regulation; yields oxidants during pathological stress|
|Peroxynitrite||Highly reactive; formed from nitric oxide and superoxide|
|Ozone||Present as an atmospheric pollutant; reacts with various molecules|
Plant-derived phenolic compounds have been shown to inhibit the initiation and progression of cancers by modulating genes regulating key physiologic processes, such as oncogenic transformation of normal cells, growth and development of tumors, and angiogenesis, and metastasis. Pre-clinical research with plant-derived phenolic compounds on cancer cell death have shown down-regulation of transcription factors NF-κB and NRF2 (nuclear factor erythroid-2 related factor), which regulate the expression of antioxidant proteins that protect against oxidative damage triggered by injury and inflammation.
In addition, plant-derived phenolic compounds down-regulate oncogenic survival kinases such as protein kinase B (Akt) and phosphoinositide 3-kinases (PI3k), cell proliferation regulators that include extracellular signal-regulated protein kinase (Erk1/2), D-type cyclins, and cyclin dependent kinases, histone deacetylases, and angiogenic factors vascular endothelial growth factor (VEGF), fibroblast growth factor receptor 1 (FGFR1), and macrophage inhibitory cytokine (MIC-1). In addition to inhibiting oncogenic proteins, phenolic compounds elevate the expression of tumor suppressor proteins
Micronutrients: Integrated Roles in Supporting the Immune System
Micronutrients such as vitamin E and selenium have been shown to work together increasing antibody titers, lymphocyte proliferation, and antiviral antibodies in animals. A deficiency of vitamin E and selenium can result in a decrease in cytolytic T lymphocyte activity and proliferation, impaired thymus and lymph node integrity, and decreased neutrophil phagocytic activity. Additionally, vitamin E and vitamin A have been shown to enhance neutrophil function.3
Magnesium May Reduce Chronic Inflammation
A meta-analysis and systematic review indicated that dietary magnesium intake is inversely associated with serum C-reactive protein levels.12-13 The authors indicated that the potential beneficial effect of magnesium intake on chronic diseases may be, at least in part, explained by inhibiting inflammation. Researchers have also reported that higher intakes of magnesium are associated with lower risk of metabolic syndrome.14 The best sources of magnesium from the diet are legumes, nuts, seeds, fish, and whole grains.15
Amino Acids May be Essential in Cellular Immunity
Amino acids are the building blocks of all protein. A diet that contains the essential amino acids is necessary for life. Data from the third National Health and Examination Survey (NHANES), a US National Survey, indicated that higher intakes of the amino acid arginine were associated with lower levels of c-reactive protein.16 The authors suggested that individuals may be able to lower their risk for cardiovascular disease by consuming more arginine-rich foods such as nuts and fish. During severe metabolic stress, including sepsis and surgery, another amino acid, glutamine, is typically depleted from muscle stores and is considered to be “conditionally essential” in these conditions.17 Additionally, glutamine has an important role in cell-mediated immunity and maintains the integrity of the intestinal mucosa.18 Protein-rich foods like beef, chicken fish, dairy products, beans, and many other foods are good food sources of glutamine. Recently, glutamine was reported to inhibit micro RNA-23 in animals, thereby protecting myocardial function from ischemia/reperfusion injury.19
Omega-3 Fatty Acids Actively Direct Resolution of Inflammation
The role of dietary omega-3 fatty acids eicosapentaenoic acid (EPA, 20:5n3), docosapentaenoic acid (DPA, 22:5n3), docosahexaenoic acid (DHA, 22:6n3), and their oxygenated derivatives are emerging as key factors in the active and sequential resolution of inflammation and physiological repair of tissues. Dietary EPA and DHA have been recognized as important modulators of the inflammatory process by shifting the cyclooxygenase-stimulated production of prostaglandins, thromboxanes, and leukotrienes from arachidonic acid (AA, 20:4n6) cell-signaling intermediates to the less-inflammatory omega-3 intermediates.
However, the understanding of genetic, molecular, and cellular mechanisms has led to a new paradigm of science called resolution pharmacology. Research has identified a superfamily of unique stereospecific mediators of inflammation resolution named resolvins or specialized pro-resolving mediators. The resolvins derived from EPA (E-series; RvE1, 2, 3), DHA (D-series;RvD1, 2, 3, 4), and AA (lipoxins; LX) have been shown in numerous pre-clinical settings to not only orchestrate the self-limiting inflammatory process, but also support repair of tissue affected by inflammation.20-22 There are other important mediators as well:
- Proteins and peptides that reduce inflammation (e.g., adrenocorticotropic hormone, annexin A1, short peptides, chemerin)
- β-galactoside binding proteins that have anti-inflammatory effects (i.e. galectin-1)
- Autocoids (e.g., adenosine, a nucleoside formed by the enzymatic activity of 5’-nucleotidases on intracellular ATP, ADP, and AMP)
- Gases (H2S and CO)
All of these mediators collectively share fundamental properties to terminate the initial inflammatory reaction and organize the “cleaning phase” within the affected tissue in an effort to return to homeostasis.20
The bioactivity identified with the formation of resolving mediators includes the inhibition of granulocyte trafficking, removal of monocytes, promotion of granulocyte cell death (apoptosis), augmentation of phagocytosis and subsequent clearance of cellular debris, and the activation of macrophage class switching (M1 to M2), resulting in a macrophage that can repair physiology and also promote tissue regeneration and repair.
However, side effects of many of the therapeutic anti-inflammatory approaches may lead to negative consequences such as immunosuppression, toxicity to tissues, and compensation by the body leading to tolerance of the therapy and reduced effectiveness. A pro-resolving strategy with pro-resolving molecules may be the desired therapeutic approach of the future, and would deliver actions already “optimized” by nature. There are many therapeutic agents that are in various stages of research using the pro-resolving therapeutic approach for a variety of health conditions including type 2 diabetes, dry eye syndrome, gingival inflammation, and pain receptivity via D series resolving receptors in patients with osteoarthritis pain.
There is evidence that lymph nodes produce 17-DHEA, which enhances antibody production. In addition, other D series resolvins have been characterized in other lymphoid tissues in mice such as the spleen. These observations suggest that the pro-resolving mediators, in addition to returning tissue to homeostasis, may also play a positive role in supporting acquired immunity.
The aging process dysregulates D and E series resolvin activity in modulating cardiosplenic and cardiorenal function following myocardial infarction in experimental animals. Resolvin dysregulation may also be a factor in age-associated neurodegenerative conditions such as Alzheimer’s disease.30 As the formation of resolvins from dietary precursors is reduced with aging, this may signal the need for a direct supplement of resolvins to support dietary intake.
Nucleotides Support Immune Function in Adults and Healthy Infants
Nucleotides are the building blocks of DNA and RNA and play key roles in many biological processes. They serve as nucleic acid precursors, physiological mediators, components of coenzymes, and sources of cellular energy.31 A nucleotide consists of a base of either cytosine, thymine, or uridine (known as pyrimidines) or adenine and guanine (known as purines), plus a molecule of pentose sugar and one or more phosphate groups.
Sources of nucleotides include de novo synthesis, recovery via salvage mechanisms, and dietary intake of normal foods, particularly meats. Nucleotides, found in normal diets, have been determined to be required for normal immune competence, intestinal development, and recovery. They may be considered “conditionally essential” in periods of rapid growth, or in the presence of regulatory or developmental factors, which interfere with full expression of the endogenous synthetic capacity.31-34 In adults fed enteral diets containing nucleotides, immune function was improved compared to a nucleotide-free diet. In addition, post-operative cancer patients fed a nucleotide formula had reduced infectious complications and reduced length of hospital stay compared to the nucleotide free diet.35
Rapidly proliferating tissues, such as in the immune system or the intestine, may not be able to fulfill the needs for cell nucleotides exclusively by de novo synthesis. When demand exceeds the ability of the body to synthesize nucleotides, the tissues can utilize the salvage pathway recovering nucleosides and nucleobases from blood and diet, and then make additional nucleotides.36 Dietary nucleotides influence lymphocyte maturation, activation, and proliferation, and affect the lymphocyte population in both the small intestine and blood. Additionally, nucleotides are involved in support of the innate immune response by enhancing macrophage phagocytosis and delayed hypersensitivity as well as allograft and tumor responses.
Prospective randomized trials in infants fed formula supplemented with nucleotides at the level found in human milk (bound and free nucleotides; 72mg/L) demonstrated that humoral immunity was enhanced, compared to infants fed control formula with no added nucleotides. Specifically, in the first year of life, infants had higher humoral vaccination response (poliovirus type 1 neutralizing antibody) when given infant formula with nucleotides.Nucleotide supplemented formulas also provided a better antibody response to immunization with Haemophillus influenza vaccine, diphtheria toxoid, and oral polio vaccine and fewer episodes of diarrhea.Additionally, infants were evaluated for cellular immunity and the cohort fed infant formula supplemented with nucleotides had increased memory/effector T-cell populations and changes in natural killer (NK) cell subtypes compared to infants fed unfortified formula. The shift in maturation and immunoregulatory subsets of the group fed the nucleotide formula had similar results as those fed human milk.
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What is The Lost Book of Remedies? The Lost Book of Remedies PDF contains a series of medicinal and herbal recipes to make home made remedies from medicinal plants and herbs. Chromic diseases and maladies can be overcome by taking the remedies outlined in this book. The writer claims that his grandfather was taught herbalism and healing whilst in active service during world war two and that he has treated many soldiers with his home made cures.
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